Publications
Featured publications on the cover of journals
Lead Guest Editor to three Special Volumes to “Biochimica et Biophysica Acta-General Subjects”
Special Volume 3 – Microcalorimetry in the Biosciences-Special Volume (2016) Volume 1860, Issue 5, 859-1042 . http://www.sciencedirect.com/science/journal/03044165/1860/5
Special Volume 2 – Transferrins: Molecular Mechanisms of Iron Transport and Disorders, (2012) Volume 1820, issue 3, 157-452 http://www.sciencedirect.com/science/article/pii/S0304416512000104
Special Volume 1 – Ferritin: Structures, Properties and Applications, (2010) Volume 1800, issue 8, 687-897 http://www.sciencedirect.com/science/article/pii/S0304416510001212
Papers
62- Ayush K. Srivastava, Aliaksandra A. Reutovich, Nathan J. Hunter, Paolo Arosio, Fadi Bou‑Abdallah. Ferritin microheterogeneity, subunit composition, functional, and physiological implications. Nature, Scientific Reports (2023) 13:19862 | https://doi.org/10.1038/s41598-023-46880-9
61- Reutovich, A.A., Srivastava, A.A., Arosio, P., Bou-Abdallah, F. Ferritin Nanocages as Efficient Nanocarriers and Promising Platforms for COVID-19 and Other Vaccines Development. Biochim. Biophys. Acta 2023, 1867 (3), 130288
60- Srivastava, A.K., Scalcione, L.J., Arosio, P., Bou-Abdallah, F. Hyperthermostable Recombinant Human Heteropolymer Ferritin Derived from a Novel Plasmid Design. Protein Science 2022, e4543. https://doi.org/10.1002/pro.4543
59- Longo, T., Kim, S., Srivastava, A.K., Hurley, L., Ji, K., Viescas, A.J., Flint, N., Foucher, A., Yates, D.M., Stach, E.A., Papaefthymiou, G.C., Bou-Abdallah, F. Micromagnetic and morphological characterization of heteropolymer human ferritin cores. Nanoscale Adv., 2022
58 - Aliaksandra A. Reutovich, Ayush K. Srivastava, Gideon L. Smith, Alexandre Foucher, Douglas M. Yates, Eric A. Stach, Georgia C. Papaefthymiou, Paolo Arosio, and Fadi Bou-Abdallah. Effect of Phosphate and Ferritin Subunit Composition on the Kinetics, Structure, and Reactivity of the Iron Core in Human Homo and Heteropolymer Ferritins. Biochemistry 2022, 61, 19, 2106–2117
57- Gideon L. Smith, Ayush K. Srivastava, Aliaksandra A. Reutovich, Nathan J. Hunter, Paolo Arosio, Artem Melman, Fadi Bou-Abdallah. Iron Mobilization from Ferritin in Yeast Cell Lysate and Physiological Implications. Int. J. Mol. Sci. 2022, 23, 6100.
56- Ayush K. Srivastava, Maura Poli, Paolo Arosio, Fadi Bou-Abdallah. A Novel Approach for the Synthesis of Human Heteropolymer Ferritins of Different H to L Subunit Ratios. Journal of Molecular Biology, 2021, 433 (19), 167198.
55- Milán, A.F., Rincón, O.A., Arango, L.B., Reutovich, A.A., Smith, G.L., Giraldo, M.A., Bou-Abdallah, F., Calderón, J.C. Calibration of Mammalian Skeletal Muscle Ca 2+ Transients Recorded with the Fast Ca 2+ Dye Mag-Fluo-4. Biochim. Biophys. Acta (BBA), 2021, 1865, 129939.
54- Smith, G.L, Reutovich, A.A., Srivastava, A.K., Reichard, R.E., Welsh, C.H., Wilkinson, T., Melman, A., Bou-Abdallah, F. Complexation of Ferrous Ions by Ferrozine, 2,2’-Bipyridine and 1,10-Phenanthroline: Implication for the Quantification of Iron in Biological Systems. J., Inorg. Biochem. 2021, 220, 111460.
53- Sharpe, E., Farragher-Gnadt, A.P., Igbanugo, M., Huber, T., Michelotti, J.C., Milenkowic. A., Ludlam. S., Walker. M., Hanes. D., Bradley, R., Bou-Abdallah, F. Comparison of antioxidant activity and extraction techniques for commercially and laboratory prepared extracts from six mushroom species. J. Agr. Food Res. 2021, 4, 100130.
52- Melman, A. Bou-Abdallah, F. Iron Mineralization and Core Dissociation in Mammalian Homopolymeric H-Ferritin: Current Understanding and Future Perspectives. Biochim. Biophys. Acta, 2020, 1864 (11), 129700.
51- Milliken, B. T., Melegari, L., Smith, G. L.*, Grohn, K., Wolfe, A., Moody, K., Bou-Abdallah, F., Doyle, R. P. Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis. RSC Medicinal Chemistry, 2020, 11, 1048.
50- Srivastava, A., Flint, N.*, Kreckel, H.*, Gryzik, H., Poli, M., Arosio, P., Bou-Abdallah, F. Thermodynamic and Kinetic Studies of the Nuclear Receptor Coactivator-4 (NCOA4) Interaction with Human Ferritin. Biochemistry, 2020. 59, 2707-2717.
49- McNally, J. R.*, Mehlenbacher, M. R.*, Luscieti, S., Smith, G. L.*, Reutovich, A. A.*, Maura, P., Arosio. P., Bou-Abdallah, F. Mutant L-chain ferritins that cause neuroferritinopathy alter ferritin functionality and iron permeability. Metallomics 2019, 11 (10), 1635 – 1647. (highlighted on the cover)
48- Bou-Abdallah, F., Flint, N.*, Wilkinson, T., Salim, S., Srivastava, A. K., Poli, M., Arosio, P., Melman, A. Ferritin Exhibits Michaelis-Menten Behavior with Oxygen but not with Iron During Iron Oxidation and Core Mineralization. Metallomics. 2019, 11 (4), 774 – 783. (highlighted on the cover)
47- Bou-Abdallah, F.; Paliakkara, J. J.*; Melman, G.; Melman, A., Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication. Pharmaceuticals 2018, 11 (4).
46- Johnson, L. E.*, Wilkinson, T., Arosio, P., Melman, A., Bou-Abdallah, F. Effect of Chaotropes on the Kinetics of Iron Release from Ferritin by Flavin Nucleotides. Biochim. Biophys. Acta, 2017, 1861, 3257–3262.
45- Tinklepaugh, J., Smith, B. M.*, Hanlon, E., Zubieta, C., Bou-Abdallah, F., Doyle, R. P. Exploring the Multiligand Binding Specificity of Saposin B Reveals Two Binding Sites. ACS Omega, 2017, 2, 7141-7145.
44- Mehlenbacher, M.*, Poli, M., Arosio, P., Santambrogio, P., Levi, S., Chasteen, N.D., Bou-Abdallah, F. Iron Oxidation and Core Formation in Recombinant Heteropolymer Ferritins”. Biochemistry, 2017, 56 (30), 3900-3912
43- Tinklepaugh, J., Smith, B.*, Nie, Y., Moody, K., Grohn, K., Bou-Abdallah, F., Doyle, R.P. Saposin B binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic Degradation by HRP. ChemPhotoChem, (featured on cover) 2017, 1 (6), 256-259 (Read inside cover profile here)
42- Spurgeon, S.*, Bou-Abdallah, F. Effect of Solvent Polarity on the Kinetics of Isomerization of 4-Anilino-4’-Nitroazobenzene. J. Thermodynamics and Catalysis, 2017, 8: 181.
41- Varden, L.*, Smith, B. M.*, Bou-Abdallah, F. Detection and Quantification of Inorganic and Organic Anions in Natural, Potable, and Wastewaters in Northern New York Using Capillary Zone Electrophoresis and Indirect UV Detection. Journal of Chromatography & Separation Techniques, 2017, Vol 8, Issue 2.
40- Varden, L.*, Bou-Abdallah, F. Detection and Separation of Inorganic Cations in Natural, Potable, and Wastewater Samples Using Capillary Zone Electrophoresis with Indirect UV Detection. American Journal of Analytical Chemistry, 2017, Vol 8, 81-94
39- Bou-Abdallah, F., Sprague, S. E., Smith, B. M., Giffune, T. R. Binding Thermodynamics of Diclofenac and Naproxen with Human and Bovine Serum Albumins: A Calorimetric and Spectroscopic Study. J. Chem Therm., 2016, 103, 299–309.
38- D. Xu, Q. Ran, Y. Xiang, L. Jiang, Britannia. M. Smith*, F. Bou-Abdallah, R. Lund, Z. Li, H. Dong. Toward Hemocompatible Self-assembling Antimicrobial Nanofibers: Synergistic Effect of Supramolecular Structure and PEGylation. RSC Advances, 2016, 6, 15911-15919
37- B. P. Huta, Matthew. R. Mehlenbacher*, Y. Nie, X-L. Lai, C. Zubieta, F. Bou-Abdallah, R. P. Doyle. The Lysosomal Protein Saposin B Binds Chloroquine. ChemMedChem, Wiley Publications, (highlighted on cover) 2016, 11, 277-282
36- F. Bou-Abdallah and Thomas Giffune*. The Thermodynamics of Protein Interactions with Essential 1st Row Transition Metals. Biochim Biophys Acta 2016, 1860 (5) 879–891
35- Bou-Abdallah, F. Special issue on “Microcalorimetry in the BioSciences—Principles and applications”, Biochim Biophys Acta 2016, 1860 (5) 859–1042
34- Matthew R. Mehlenbacher, Fadi Bou-Abdallah, Xing Xin Liu, Artem Melman. Calorimetric Studies of Ternary Complexes of Ni(II) and Cu(II) Nitrilotriacetic Acid and N-Acetyloligohistidines. Inorganica Chimica Acta, 2015, Volume 437, 152–158.
33– Elise Abi-Khalil, Diego Segond, Tyson Terpstra, Gwenaëlle André-Leroux, Mireille Kallassy, Didier Lereclus, Fadi Bou-Abdallah, Christina Nielsen-Leroux. Heme interplay between IlsA and IsdC: Two structurally different surface proteins from Bacillus cereus. Biochim Biophys Acta 2015, Vol 1850, Issue 9, 1930-1941.
32- Tyson Terpstra, Justin McNally, Thi Hong Lien Han, Nguyet Thanh Ha Duong, Jean-Michel El-Hage Chahine, and Fadi Bou-Abdallah. Direct Thermodynamic and Kinetic Measurements of Fe2+ and Zn2+ Binding to Human Serum Transferrin. Journal of Inorganic Biochemistry, 2014, Volume 136, 24–32.
31– Brian Phillip Huta, Matthew Mehlenbacher, Allison Roberts, Elizabeth Waters, Vivian Yaci Yu, Fadi Bou-Abdallah, and Robert P Doyle. The Antimalarial Drug Atovaquone Binds to Saposin B with Comparable Affinity to Coenzyme Q10. Med. Chem. Commun., 2014.
30- Diego Segond, Elise Abi Khalil, Christophe Buisson, Nadine Daou, Mireille Kallassy, Didier Lereclus, Paolo Arosio, Fadi Bou-Abdallah and Christina Nielsen Le Roux. Iron Acquisition in Bacillus cereus: The Roles of IlsA and Bacillibactin on exogenous Ferritin Iron Mobilization. PLoS Pathogens. 2014 | Volume 10 | Issue 2 | e1003935
29- Fadi Bou-Abdallah et al., The Functionality of the Three-Sited Ferroxidase Center of E. coli Bacterial Ferritin (EcFtnA), Biochemistry 2014, 53 (3), pp 483–495
28– Melman, G., Bou-Abdallah, F., Vane, E., Maura, P., Arosio, P., Melman, A. Iron release from ferritin by flavin nucleotides. Biochim Biophys. Acta 2013; 1830: 4669–4674
27– Bou-Abdallah, F. Editorial.Does Iron Release from Transferrin Involve a Reductive Process? Bioenergetics 2012; 1-3
26– Bou-Abdallah, F. Editorial. Transferrins: Molecular mechanisms of iron transport and disorders. Biochim Biophys. Acta 2012; 1820: 157–158
25– Bou-Abdallah. F., Terpstra*, T. The Thermodynamic and Binding Properties of the Transferrins as Studied by Isothermal Titration Calorimetry. Biochim. et Biophys. Acta, 2012; 1800 (3), 318-325
24– Bou-Abdallah, F., McNally*, J., Liu, X. X., Melman, A. Oxygen Catalyzed Mobilization of Iron from Ferritin by Iron(III) Chelate Ligands, Chem. Comm., 2011; 47, 731–733
23– Bou-Abdallah. F. The Iron Redox and Hydrolysis Chemistry of the Ferritins. Biochim. et Biophys. Acta 2010; 1800: 719–731
22– Bou-Abdallah, F. Editorial. Special issue on ferritin. Biochim Biophys. Acta, 2010; 1800: 687–688
21– Mason, A. B., Byrne, S. L., Everse, S. J., Roberts, S. A., Smith, V. C., MacGillivray, R. T. A., Kandemir*, B., Bou-Abdallah, F. A Loop in the N-Lobe of Human Serum Transferrin is Critical to Binding to the Transferrin Receptor as Revealed by Mutagenesis, ITC, and Epitope Mapping. J. Mol. Recognit. 2009; 22: 521–529
20– Bou-Abdallah, F., Zhao, G., Biasiotto, G., Poli, M., Arosio, P., Chasteen, N. D. Facilitated Diffusion of Iron(II) and Dioxygen Substrates into Human H-Chain Ferritin. A Fluorescence and Absorbance Study Employing the Ferroxidase Center Substitution Y34W. J. Am. Chem. Soc., 2008, 130 (52), 17801-17811
19– Bou-Abdallah, F., Chasteen, N. D. Spin concentration measurements of high-spin (g’ = 4.3) rhombic iron(III) ions in biological samples: theory and application. J. Biol. Inorg. Chem., 2008, 13, 15-24
18– Bou-Abdallah, F., Carney, E., Chasteen, N. D., Arosio, P., Viescas, A. J., Papaefthymiou, G. C. A comparative Mössbauer study of the mineral cores of human H-chain ferritin employing dioxygen and hydrogen peroxide as iron oxidants. Biophys. Chem., 2007, 130, 114–121
17– Guo, M., Perez, C., Wei, Y., Rapoza, E., Su, G., Bou-Abdallah, F., Chasteen, N. D. Iron-binding properties of plant phenolics and cranberry’s bio-effects. Dalton Transactions, 2007, 43, 4951-4961
16– Bou-Abdallah, F., Chasteen N. D., Lesser M. P. Green Fluorescence Protein Quenches Superoxide Radicals. Biochim. Biophys. Acta, 2006, 1760,1690–1695
15– Bou-Abdallah, F., Woodhall, M. R., Velazquez-Campoy, A., Andrews, S. C., Chasteen, N. D. Thermodynamic Analysis of Ferrous Ion Binding to Escherichia coli Ferritin EcFtnA. Biochemistry, 2005, 44, 13837-13846
14– Bou-Abdallah, F., Zhao, G., Mayne, H., Arosio, P., Chasteen, N. D. Origin of the Unusual Kinetics of Iron Deposition in Human H-Chain Ferritin. J. Am. Chem. Soc., 2005, 127, 3885-3893
13– Bou-Abdallah, F., Santambrogio, P., Levi, S., Arosio, P., Chasteen, N. D. Unique Iron Binding and oxidation Properties of Human Mitochondrial Ferritin. A Comparative Analysis With Human H-Chain ferritin. J. Mol. Biol., 2005, 347, 543-554
12– Bou-Abdallah, F., Adinolfi, S., Pastore, A., Laue, T. M., Chasteen, N. D. Iron Binding and Kinetics of Oxidation in Frataxin CyaY of Escherichia coli. J. Mol.Biol., 2004, 341, 605-615
11– Bou-Abdallah, F., Biasiotto, G., Arosio, P., Chasteen, N. D. The Putative Nucleation Site in Human H-Chain Ferritin is Not Required for Mineralization of The Iron Core. Biochemistry, 2004, 43, 4332-4337
10– Bou-Abdallah, F., Arosio, P., Levi, S., Janus-Chandler, C., Chasteen, N.D. Defining Metal Ion Inhibitor Interactions with Recombinant Human H-chain Ferritins and Site-Directed Variants. An Isothermal Titration Calorimetry Study. J. Biol. Inorg. Chem., 2003, 8, 489-497
9– Zhao, G., Bou-Abdallah, F., Arosio, P., Levi, S., Janus-Chandler, C., Chasteen, N. D. Multiple Pathways for Mineral Core Formation in Mammalian Apoferritin. The Role of Hydrogen Peroxide. Biochemistry, 2003, 42, 3142-3150
8– Bou-Abdallah, F., Lewin, A. C., Le Brun, N. E., Moore, G. R., Chasteen N. D. Iron Detoxification Properties of Escherichia coli Bacterioferritin. Attentuation of Oxyradical Chemistry. J. Biol. Chem., 2002, 277, 37064-37069
7– Bou-Abdallah, F., Arosio, P., Santambrogio, P., Yang, X., Janus-Chandler, C., Chasteen, N. D. Ferrous Ion Binding to Recombinant Human H-Chain Ferritin. An Isothermal Titration Calorimetry Study. Biochemistry, 2002, 41, 11184-11191
6– Bou-Abdallah, F., Papaefthymiou, G. C., Scheswohl, D. M., Stanga, S. D., Arosio P., Chasteen, N. D. Mu-1,2-Peroxobridged Di-Iron(III) Dimer Formation in Human H-Chain Ferritin. Biochem. J., 2002, 364, 57-63
5– Zhao, G., Bou-Abdallah, F., Yang, X., Arosio, P., Chasteen, N. D. Is Hydrogen Peroxide Produced during Iron(II) Oxidation in Mammalian Apoferritins? Biochemistry, 2001, 40, 10832-10838
4– Bou-Abdallah, F., El Hage Chahine, J. M. Transferrins, Iron Release from Lactoferrin. J. Mol. Biol., 2000, 303, 255-266
3– Pakdaman, R., Bou-Abdallah, F., El Hage Chahine, J. M. Transferrins, Is a Mixed Chelate-Protein Ternary Complex Involved in The Mechanism of Iron Uptake by Serum-Transferrin in-vitro? J. Mol. Biol., 1999, 293, 1273-1284
2– Bou-Abdallah, F., El Hage Chahine, J. M. Transferrins, The Mechanism of Iron Release by Ovotransferrin. Eur. J. Biochem., 1999, 263, 912-920
1– Bou-Abdallah, F., El Hage Chahine, J. M. Hen Ovo-Transferrin, Interaction with Bicarbonate and Iron Uptake. Eur. J. Biochem., 1998, 258, 1022-1031